OICC Press International Journal of Biophotonics and Biomedical Engineering (IJBBE) 2980-9037 4 2 2025 03 28 Bio-Photonic Sensor Using Structurally Chiral Mediums as a Basal Cancer Cell Detection 49 58 10.71498/ijbbe.2024.1192716 EN Nadia Ghorani Department of Laser and Optical Engineering, University of Bonab, Bonab, Iran Amir Madani Department of Laser and Optical Engineering, University of Bonab, Bonab, Iran Samad Roshan Entezar Department of Physics, Tabriz University, Tabriz, Iran Journal Article 2025 03 28 In this article, a high-accuracy novel optical biosensor consisting of a structurally chiral medium with 4 ̅2m point group symmetry and a silver metallic defect layer under the Sarid configuration is investigated as a theoretical study . We used incident light with p polarization and used the 4 × 4 transfer matrix method for absorption spectrum calculations. Surface plasma polarities (SPP) modes on the interface between a metallic layer and SCM hav e also been investigated. One of the advantages of using the SCM in this configuration is that it allows us to have several plasmonic and waveguide modes. We have also determined the difference between plasmonic modes and waveguide modes.  The resonance angles observed in the absorption spectrum are very sensitive to changes in the fluid placed on top of the sensor and this sensor has a very high-quality factor that distinguishes it from other sensors. The effect of the tilt angle of the SCM has also been investigated. These combinations make the proposed designed sensor unique for performing label-free bioassays in the detection of cancer cells. The basis of this research is to detect cancer cells, which the designed sensor can detect with high sensitivity factors.