10.57647/pibm.2025.1403.01

In-vitro Evaluation of Hydroxyapatite Reinforced Glass-ceramic Composites for Biomedical Applications

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  • Khushi Bijalwan1,
  • Karthiga Parthiban1,2,
  • Sutanu Dutta1,
  • Debolina Saha1,
  • Sumana Ghosh*1,2,
  1. Biomaterials and Medical Devices Division, CSIR-Central Glass and Ceramic Research Institute (CSIR-CGCRI), Kolkata-700032, India
  2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad- 201002, India

Received: 2025-03-04

Accepted: 2025-07-20

Published in Issue 2025-09-30

Copyright (c) 2025 Khushi Bijalwan, Karthiga Parthiban, Sutanu Dutta, Debolina Saha, Sumana Ghosh (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Bijalwan, K., Parthiban, K., Dutta, S., Saha, D., & Ghosh, S. (2025). In-vitro Evaluation of Hydroxyapatite Reinforced Glass-ceramic Composites for Biomedical Applications. Progress in Biomaterials, 14(03). https://doi.org/10.57647/pibm.2025.1403.01
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Abstract

Current study investigated the effect of hydroxyapatite inclusion in apatite based glass-ceramic matrix on mechanical properties, bioactivity, biocompatibility and antibacterial property of the resultant composites. Density, hardness and compressive strength of 50 wt.% hydroxyapatite reinforced apatite-diopside glass-ceramic composites were 2.433 g.cm-3, 1.374 GPa and 1.0305 GPa whereas these values were 2.179 g.cm-3, 1.833 GPa and 1.374 GPa for 50 wt.% hydroxyapatite reinforced apatite-wollastonite glass-ceramic composites, respectively. The bioactivity study showed that the developed glass-ceramics and composites were bioactive in nature. In antibacterial study it was found that all the glass-ceramics and composites were capable of resisting bacterial attack efficiently. However, glass-ceramics had the best antibacterial efficacy. In vitro cytotoxicity assessment showed non-toxicity of glass-ceramics and composites. Thus, the experimental studies indicated that the developed glass-ceramics and composites might be used for bone filler as well as dental filler applications. However, in-vivo study was essential to confirm their suitability for the said applications.

Keywords

  • Hydroxyapatite,
  • Glass-ceramic,
  • Composites,
  • Characterization,
  • Dental filler application
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